POE2 - Mouse clicks not registering

Helped me to set no skill for Left Mouse Button. But when it is Galvanic shards - interaction does not work...

And I cannot attack anymore ;/ interaction works, but attack is broken totally.

I had the same issue where I couldn't pickup items, click waypoints or checkpoints etc., and apparently the problem was using "Load Permafrost Bolts" on left mouse button disables clicking/pickup. Haven't checked but assume any "skill switching" gems on LMB could cause this issue.

EDIT: v. 0.3

can you please fix this mouse curser issue.
It is not our sofware that is causing this issue.
In the log in screen if you go to the top left corner to change language, it works fine, but as soon as you move the curser down there becomes this 1 inch gap between the curser and where the curser should be.
Game is unplayable.....

Same problem, cant play the game

Sept 22 2025 - Just ran into the exact same issue.

For me, it happened when I clicked on the skill description for Spark and selected in the bottom right corner "Always Attack Without Moving".

I unchecked that option and it fixed it.

To note, that skill was set in my first slot (the one also assigned to left mouse click), so maybe it has something to do with spell activation in town...